Protective effects of diisopropyl 1,3-dithiol-2-ylidene malonate (NKK-105) on liver injury by carbon tetrachloride (CCl4).
نویسندگان
چکیده
منابع مشابه
Anti-alcohol action of hepaticoactivator (NKK-105) on motoricity and EEG in experimental animals and man.
The effects of a hepaticoactivator, diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105), on motoricity and EEG were observed int he rat, mouse, cat and man. NKK-105 suppressed the effects of ethanol (1,000-3,000 mg/kg, p.o., in mice and rats), e.g. the blood alcohol concentration of NKK-105 treated subjects was significantly lower than that of untreated controls. NKK-105, in 100-300 mg/kg p.o...
متن کاملPreventive effect of novel nanomissile of silymarin on liver injury induced by carbon tetrachloride in rat
Background and Aim: Silymarin, obtained from Silybum marianum has hepatoprotective effects and antioxidant activity and has been used in the treatment of liver diseases. Because of its poor aqueous solubility and low bioavailability its use has been limited. The aim of this study was to prepare a new and inexpensive formulation of silymarin using simple dissolution methods and compare its hepat...
متن کاملProtective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice.
Oxidative stress has been recognized as a critical pathogenetic mechanism for the initiation and the progression of hepatic injury in a variety of liver disorders. Antioxidants, including many natural compounds or extracts, have been used to cope with liver disorders. The present study was designed to investigate the hepatoprotective effects of cassia seed ethanol extract (CSE) in carbon tetrac...
متن کاملProtective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride in the rat.
The influence of cholestyramine and chenodeoxycholic acid on the induction of liver cirrhosis by carbon tetrachloride was investigated in the Wistar rat. The addition of 1.3% cholestyramine to the diet of the experimental animals inhibited to a large extent the induction of cirrhosis. While all the animals subjected to carbon tetrachloride exposure plus basal diet and those to carbon tetrachlor...
متن کاملProtective Effects of Polydatin from Polygonum cuspidatum against Carbon Tetrachloride-Induced Liver Injury in Mice
Polydatin is one of main compounds in Polygonum cuspidatum, a plant with both medicinal and nutritional value. The possible hepatoprotective effects of polydatin on acute liver injury mice induced by carbon tetrachloride (CCl(4)) and the mechanisms involved were investigated. Intraperitoneal injection of CCl(4) (50 µl/kg) resulted in a significant increase in the levels of serum aspartate amino...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1982
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.7.13